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How long does Zyban take to work for smoking? You begin taking bupropion daily, 1 to 2 weeks before you quit smoking. This builds up the level of medicine in your body. You take bupropion for 7 to 12 weeks after you stop using tobacco. You can take it for as long as 6 months to a year. Is nicotine like caffeine? The evidence shows smoking is the killer, not nicotine, they say. Some studies show nicotine, like caffeine, can even have positive effects. It's a stimulant, which raises the heart rate and increases the speed of sensory information processing, easing tension and sharpening the mind.
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